Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production

Alzheimer’s disease (AD) is characterized by neuronal and synaptic loss. One process that could contribute to this loss is the intracellular caspase cleavage of the amyloid precursor protein (APP) resulting in release of the toxic C-terminal 31-amino acid peptide APP-C31 along with the production of...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: Poksay, Karen S., Sheffler, Douglas J., Spilman, Patricia, Campagna, Jesus, Jagodzinska, Barbara, Descamps, Olivier, Gorostiza, Olivia, Matalis, Alex, Mullenix, Michael, Bredesen, Dale E., Cosford, Nicholas D. P., John, Varghese
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309220/
https://ncbi.nlm.nih.gov/pubmed/28261092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00046
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