Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production

Alzheimer’s disease (AD) is characterized by neuronal and synaptic loss. One process that could contribute to this loss is the intracellular caspase cleavage of the amyloid precursor protein (APP) resulting in release of the toxic C-terminal 31-amino acid peptide APP-C31 along with the production of...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Poksay, Karen S., Sheffler, Douglas J., Spilman, Patricia, Campagna, Jesus, Jagodzinska, Barbara, Descamps, Olivier, Gorostiza, Olivia, Matalis, Alex, Mullenix, Michael, Bredesen, Dale E., Cosford, Nicholas D. P., John, Varghese
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309220/
https://ncbi.nlm.nih.gov/pubmed/28261092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00046
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