The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer’s model

Tropisetron was identified in a screen for candidates that increase the ratio of the trophic, neurite-extending peptide sAPPα to the anti-trophic, neurite-retractive peptide Aβ, thus reversing this imbalance in Alzheimer’s disease (AD). We describe a hierarchical screening approach to identify such...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Spilman, Patricia, Descamps, Olivier, Gorostiza, Olivia, Peters-Libeu, Clare, Poksay, Karen S., Matalis, Alexander, Patent, Alexander, Rao, Rammohan, John, Varghese, Bredesen, Dale E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001856/
https://ncbi.nlm.nih.gov/pubmed/24389031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2013.12.029
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados