The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer’s model

Tropisetron was identified in a screen for candidates that increase the ratio of the trophic, neurite-extending peptide sAPPα to the anti-trophic, neurite-retractive peptide Aβ, thus reversing this imbalance in Alzheimer’s disease (AD). We describe a hierarchical screening approach to identify such...

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Hauptverfasser: Spilman, Patricia, Descamps, Olivier, Gorostiza, Olivia, Peters-Libeu, Clare, Poksay, Karen S., Matalis, Alexander, Patent, Alexander, Rao, Rammohan, John, Varghese, Bredesen, Dale E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001856/
https://ncbi.nlm.nih.gov/pubmed/24389031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2013.12.029
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