Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2

Targeting of molecular pathways involved in the cell-to-cell propagation of pathological tau species is a novel approach for development of disease-modifying therapies that could block tau pathology and attenuate cognitive decline in patients with Alzheimer’s disease and other tauopathies. We discov...

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Bibliografiske detaljer
Udgivet i:Biochem Biophys Res Commun
Main Authors: Bilousova, Tina, Elias, Chris, Miyoshi, Emily, Alam, Mohammad-Parvez, Zhu, Chunni, Campagna, Jesus, Vadivel, Kanagasabai, Jagodzinska, Barbara, Gylys, Karen, John, Varghese
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5956110/
https://ncbi.nlm.nih.gov/pubmed/29604274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.03.209
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