Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimerșs Disease

We report the discovery of a novel class of compounds that function as dual inhibitors of the enzymes neutral sphingomyelinase-2 (nSMase2) and acetylcholinesterase (AChE). Inhibition of these enzymes provides a unique strategy to suppress the propagation of tau pathology in the treatment of Alzheime...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:ACS Chem Biol
Auteurs principaux: Bilousova, Tina, Simmons, Bryan J., Knapp, Rachel R., Elias, Chris J., Campagna, Jesus, Melnik, Mikhail, Chandra, Sujyoti, Focht, Samantha, Zhu, Chunni, Vadivel, Kanagasabai, Jagodzinska, Barbara, Cohn, Whitaker, Spilman, Patricia, Gylys, Karen H., Garg, Neil K., John, Varghese
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8297715/
https://ncbi.nlm.nih.gov/pubmed/32352753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00311
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires