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Structural and Functional Alterations in Amyloid-β Precursor Protein Induced by Amyloid-β Peptides
Alzheimer's disease-associated amyloid-β (Aβ) peptide is neurotoxic as an oligomer, but not as a monomer, by an unknown mechanism. We showed previously that Aβ interacts with the amyloid-β precursor protein (AβPP), leading to caspase cleavage and cell death induction. To characterize this struc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001850/ https://ncbi.nlm.nih.gov/pubmed/21471643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-101938 |
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