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Structural and Functional Alterations in Amyloid-β Precursor Protein Induced by Amyloid-β Peptides

Alzheimer's disease-associated amyloid-β (Aβ) peptide is neurotoxic as an oligomer, but not as a monomer, by an unknown mechanism. We showed previously that Aβ interacts with the amyloid-β precursor protein (AβPP), leading to caspase cleavage and cell death induction. To characterize this struc...

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Autors principals: Libeu, Clare Peters, Poksay, Karen S., John, Varghese, Bredesen, Dale E.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001850/
https://ncbi.nlm.nih.gov/pubmed/21471643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-101938
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