Pharmacological Modulation of NMDA Receptor Activity and the Advent of Negative and Positive Allosteric Modulators

Por Monaghan, Daniel T., Irvine, Mark W., Costa, Blaise Mathias, Fang, Guangyu, Jane, David E.
Publicado em 2012

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo

Por Wallis, James L, Irvine, Mark W, Jane, David E, Lodge, David, Collingridge, Graham L, Bortolotto, Zuner A
Publicado no Hippocampus (2015)

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

Por Chopra, Divyan A., Sapkota, Kiran, Irvine, Mark W., Fang, Guangyu, Jane, David E., Monaghan, Daniel T., Dravid, Shashank M.
Publicado no Sci Rep (2017)

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-Methyl-D-Aspartate receptors

Por Irvine, Mark W., Costa, Blaise M., Volianskis, Arturas, Fang, Guangyu, Ceolin, Laura, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.
Publicado em 2012

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid

Por Costa, Blaise Mathias, Irvine, Mark W., Fang, Guangyu, Eaves, Richard J., Mayo-Martin, Maria Belen, Laube, Bodo, Jane, David E., Monaghan, Daniel T.
Publicado em 2011

N-Methyl-d-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in...

Por Costa, Blaise Mathias, Feng, Bihua, Tsintsadze, Timur S., Morley, Richard M., Irvine, Mark W., Tsintsadze, Vera, Lozovaya, Natasha A., Jane, David E., Monaghan, Daniel T.
Publicado em 2009

A Novel Family of Negative and Positive Allosteric Modulators of NMDA Receptors

Por Costa, Blaise Mathias, Irvine, Mark W., Fang, Guangyu, Eaves, Richard J., Mayo-Martin, Marie Belen, Skifter, Donald A., Jane, David E., Monaghan, Daniel T.
Publicado em 2010

Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro

Por Volianskis, Arturas, Bannister, Neil, Collett, Valerie J, Irvine, Mark W, Monaghan, Daniel T, Fitzjohn, Stephen M, Jensen, Morten S, Jane, David E, Collingridge, Graham L
Publicado em 2013

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

Por France, Grace, Fernández-Fernández, Diego, Burnell, Erica S., Irvine, Mark W., Monaghan, Daniel T., Jane, David E., Bortolotto, Zuner A., Collingridge, Graham L., Volianskis, Arturas
Publicado no Neuropharmacology (2017)

Investigation of the Structural Requirements for N-Methyl-D-Aspartate Receptor Positive and Negative Allosteric Modulators Based on 2-Naphthoic Acid

Por Irvine, Mark W., Fang, Guangyu, Sapkota, Kiran, Burnell, Erica S., Volianskis, Arturas, Costa, Blaise M., Culley, Georgia, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.
Publicado no Eur J Med Chem (2018)

Mechanism and properties of positive allosteric modulation of N-Methyl-D-Aspartate receptors by 6-alkyl 2-naphthoic acid derivatives

Por Sapkota, Kiran, Irvine, Mark W., Fang, Guangyu, Burnell, Erica S., Bannister, Neil, Volianskis, Arturas, Culley, Georgia R., Dravid, Shashank M., Collingridge, Graham L., Jane, David E., Monaghan, Daniel T.
Publicado no Neuropharmacology (2017)

The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site

Por Safar, Fatemah, Hurdiss, Elliot, Erotocritou, Marios, Greiner, Timo, Lape, Remigijus, Irvine, Mark W., Fang, Guangyu, Jane, David, Yu, Rilei, Dämgen, Marc A., Biggin, Philip C., Sivilotti, Lucia G.
Publicado no J Biol Chem (2017)

Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators

Por Irvine, Mark W., Fang, Guangyu, Eaves, Richard, Mayo-Martin, Maria B., Burnell, Erica S., Costa, Blaise M., Culley, Georgia R., Volianskis, Arturas, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.
Publicado no Synthesis (Stuttg) (2015)

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Por Wang, Jue Xiang, Irvine, Mark W., Burnell, Erica S., Sapkota, Kiran, Thatcher, Robert J., Li, Minjun, Simorowski, Noriko, Volianskis, Arturas, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E., Furukawa, Hiro
Publicado no Nat Commun (2020)

The NMDA receptor as a target for cognitive enhancement

Por Collingridge, Graham L., Volianskis, Arturas, Bannister, Neil, France, Grace, Hanna, Lydia, Mercier, Marion, Tidball, Patrick, Fang, Guangyu, Irvine, Mark W., Costa, Blaise M., Monaghan, Daniel T., Bortolotto, Zuner A., Molnár, Elek, Lodge, David, Jane, David E.
Publicado no Neuropharmacology (2012)

Piperazine-2,3-dicarboxylic acid Derivatives as Dual Antagonists of NMDA and GluK1-Containing Kainate Receptors

Por Irvine, Mark W., Costa, Blaise M., Dlaboga, Daniel, Culley, Georgia, Hulse, Richard, Scholefield, Caroline L., Atlason, Palmi, Fang, Guangyu, Eaves, Richard, Morley, Richard, Mayo-Martin, Maria B., Amici, Mascia, Bortolotto, Zuner A., Donaldson, Lucy, Collingridge, Graham L., Molnár, Elek, Monaghan, Daniel T., Jane, David E.
Publicado em 2011