N-Methyl-d-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat Hippocampal CA3-CA1 Synapse

N-Methyl-d-aspartate (NMDA) receptor antagonists that are highly selective for specific NMDA receptor 2 (NR2) subunits have several potential therapeutic applications; however, to date, only NR2B-selective antagonists have been described. Whereas most glutamate binding site antagonists display a com...

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Autori principali: Costa, Blaise Mathias, Feng, Bihua, Tsintsadze, Timur S., Morley, Richard M., Irvine, Mark W., Tsintsadze, Vera, Lozovaya, Natasha A., Jane, David E., Monaghan, Daniel T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2009
Soggetti:
Neuropharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775268/
https://ncbi.nlm.nih.gov/pubmed/19684252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.156752
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