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Mechanism and properties of positive allosteric modulation of N-Methyl-D-Aspartate receptors by 6-alkyl 2-naphthoic acid derivatives

The theory that N-methyl-D-aspartate receptor (NMDAR) hypofunction is responsible for the symptoms of schizophrenia is well supported by many pharmacological and genetic studies. Accordingly, positive allosteric modulators (PAMs) that augment NMDAR signaling may be useful for treating schizophrenia....

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Bibliografske podrobnosti
izdano v:Neuropharmacology
Main Authors: Sapkota, Kiran, Irvine, Mark W., Fang, Guangyu, Burnell, Erica S., Bannister, Neil, Volianskis, Arturas, Culley, Georgia R., Dravid, Shashank M., Collingridge, Graham L., Jane, David E., Monaghan, Daniel T.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623084/
https://ncbi.nlm.nih.gov/pubmed/28709671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.07.007
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