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A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified but their effects on NMDAR gating remain largely unknown. To this end, we tested the effect of a newly developed molecule UBP684 on GluN1/Glu...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Chopra, Divyan A., Sapkota, Kiran, Irvine, Mark W., Fang, Guangyu, Jane, David E., Monaghan, Daniel T., Dravid, Shashank M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537304/
https://ncbi.nlm.nih.gov/pubmed/28761055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07292-8
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