A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified but their effects on NMDAR gating remain largely unknown. To this end, we tested the effect of a newly developed molecule UBP684 on GluN1/Glu...

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Udgivet i:Sci Rep
Main Authors: Chopra, Divyan A., Sapkota, Kiran, Irvine, Mark W., Fang, Guangyu, Jane, David E., Monaghan, Daniel T., Dravid, Shashank M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537304/
https://ncbi.nlm.nih.gov/pubmed/28761055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07292-8
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