Genetic Analysis of Adult-Onset Autoimmune Diabetes

Por Howson, Joanna M.M., Rosinger, Silke, Smyth, Deborah J., Boehm, Bernhard O., Todd, John A.
Publicado em 2011

A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong CTLA-4 gene association

Por Howson, Joanna M. M., Dunger, David B., Nutland, Sarah, Stevens, Helen, Wicker, Linda S., Todd, John A.
Publicado em 2007

NKG2D - RAE-1 receptor-ligand variation does not account for the Natural Killer cell defect in nonobese diabetic mice

Por Maier, Lisa M., Howlett, Sarah, Rainbow, Kara, Clark, Jan, Howson, Joanna M.M., Todd, John A., Wicker, Linda S.
Publicado em 2008

Analysis of the Type 2 Diabetes Gene, TCF7L2, in 13,795 Type 1 Diabetes Cases and Controls

Por Field, Sarah F., Howson, Joanna M.M., Smyth, Deborah J., Walker, Neil M., Todd, John A., Dunger, David B.
Publicado em 2006

Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct

Por Howson, Joanna M.M., Stevens, Helen, Smyth, Deborah J., Walker, Neil M., Chandler, Kyla A., Bingley, Polly J., Todd, John A.
Publicado em 2011

FUT2 Nonsecretor Status Links Type 1 Diabetes Susceptibility and Resistance to Infection

Por Smyth, Deborah J., Cooper, Jason D., Howson, Joanna M.M., Clarke, Pamela, Downes, Kate, Mistry, Trupti, Stevens, Helen, Walker, Neil M., Todd, John A.
Publicado em 2011

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

Por Saleh, Nada M, Raj, Srilakshmi M, Smyth, Deborah J, Wallace, Chris, Howson, Joanna M M, Bell, Louise, Walker, Neil M, Stevens, Helen E, Todd, John A
Publicado em 2011

No Evidence of Association or Interaction between the IL4RA, IL4, and IL13 Genes in Type 1 Diabetes

Por Maier, Lisa M., Chapman, Juliet, Howson, Joanna M. M., Clayton, David G., Pask, Rebecca, Strachan, David P., McArdle, Wendy L., Twells, Rebecca C. J., Todd, John A.
Publicado em 2005

Experimental aspects of copy number variant assays at CCL3L1

Por Field, Sarah F., Howson, Joanna M. M., Maier, Lisa M., Walker, Susan, Walker, Neil M, Smyth, Deborah J., Armour, John A. L., Clayton, David G., Todd, John A.
Publicado em 2009

An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes

Por Swafford, Austin D.-E., Howson, Joanna M.M., Davison, Lucy J., Wallace, Chris, Smyth, Deborah J., Schuilenburg, Helen, Maisuria-Armer, Meeta, Mistry, Trupti, Lenardo, Michael J., Todd, John A.
Publicado em 2011

Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases

Por Plagnol, Vincent, Howson, Joanna M. M., Smyth, Deborah J., Walker, Neil, Hafler, Jason P., Wallace, Chris, Stevens, Helen, Jackson, Laura, Simmonds, Matthew J., Bingley, Polly J., Gough, Stephen C., Todd, John A.
Publicado em 2011

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

Por Hu, Xinli, Deutsch, Aaron J, Lenz, Tobias L, Onengut-Gumuscu, Suna, Han, Buhm, Chen, Wei-Min, Howson, Joanna M M, Todd, John A, de Bakker, Paul I W, Rich, Stephen S, Raychaudhuri, Soumya
Publicado no Nat Genet (2015)

Regression Mapping of Association between the Human Leukocyte Antigen Region and Graves Disease

Por Simmonds, Matthew J., Howson, Joanna M. M., Heward, Joanne M., Cordell, Heather J., Foxall, Helen, Carr-Smith, Jackie, Gibson, Sarah M., Walker, Neil, Tomer, Yaron, Franklyn, Jayne A., Todd, John A., Gough, Stephen C. L.
Publicado em 2005

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients

Por Downes, Kate, Marcovecchio, M. Loredana, Clarke, Pamela, Cooper, Jason D., Ferreira, Ricardo C., Howson, Joanna M. M., Jolley, Jennifer, Nutland, Sarah, Stevens, Helen E., Walker, Neil M., Wallace, Chris, Dunger, David B., Todd, John A.
Publicado em 2013

Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes

Por Cooper, Nicholas J., Shtir, Corina J., Smyth, Deborah J., Guo, Hui, Swafford, Austin D., Zanda, Manuela, Hurles, Matthew E., Walker, Neil M., Plagnol, Vincent, Cooper, Jason D., Howson, Joanna M.M., Burren, Oliver S., Onengut-Gumuscu, Suna, Rich, Stephen S., Todd, John A.
Publicado no Hum Mol Genet (2015)

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

Por Howson, Joanna M.M., Cooper, Jason D., Smyth, Deborah J., Walker, Neil M., Stevens, Helen, She, Jin-Xiong, Eisenbarth, George S., Rewers, Marian, Todd, John A., Akolkar, Beena, Concannon, Patrick, Erlich, Henry A., Julier, Cécile, Morahan, Grant, Nerup, Jørn, Nierras, Concepcion, Pociot, Flemming, Rich, Stephen S.
Publicado em 2012

CD226 Gly307Ser association with multiple autoimmune diseases

Por Hafler, Jason P, Maier, Lisa M, Cooper, Jason D, Plagnol, Vincent, Hinks, Anne, Simmonds, Matthew J, Stevens, Helen, Walker, Neil, Healy, Barry, Howson, Joanna M M, Maisuria, Meeta, Duley, Simon, Coleman, Gillian, Gough, Stephen C L, Worthington, Jane, Kuchroo, Vijay K., Wicker, Linda S, Todd, John A
Publicado em 2008

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Por Nejentsev, Sergey, Howson, Joanna M. M., Walker, Neil M., Szeszko, Jeffrey, Field, Sarah F., Stevens, Helen E., Reynolds, Pamela, Hardy, Matthew, King, Erna, Masters, Jennifer, Hulme, John, Maier, Lisa M., Smyth, Deborah, Bailey, Rebecca, Cooper, Jason D., Ribas, Gloria, Campbell, R. Duncan, Clayton, David G., Todd, John A.
Publicado em 2007

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

Por Ferreira, Ricardo C., Freitag, Daniel F., Cutler, Antony J., Howson, Joanna M. M., Rainbow, Daniel B., Smyth, Deborah J., Kaptoge, Stephen, Clarke, Pamela, Boreham, Charlotte, Coulson, Richard M., Pekalski, Marcin L., Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S., Butterworth, Adam S., Malarstig, Anders, Danesh, John, Todd, John A.
Publicado em 2013

Haplotype Structure, LD Blocks, and Uneven Recombination Within the LRP5 Gene

Por Twells, Rebecca C.J., Mein, Charles A., Phillips, Michael S., Hess, J. Fred, Veijola, Riitta, Gilbey, Matthew, Bright, Matthew, Metzker, Michael, Lie, Benedicte A., Kingsnorth, Amanda, Gregory, Edward, Nakagawa, Yusuke, Snook, Hywel, Wang, William Y.S., Masters, Jennifer, Johnson, Gillian, Eaves, Iain, Howson, Joanna M.M., Clayton, David, Cordell, Heather J., Nutland, Sarah, Rance, Helen, Carr, Philippa, Todd, John A.
Publicado em 2003