An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes

OBJECTIVE: IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide association (GWA) studies have linked a region of the 3′-UTR of IKZF1 with C-ALL susc...

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Autors principals: Swafford, Austin D.-E., Howson, Joanna M.M., Davison, Lucy J., Wallace, Chris, Smyth, Deborah J., Schuilenburg, Helen, Maisuria-Armer, Meeta, Mistry, Trupti, Lenardo, Michael J., Todd, John A.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2011
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046822/
https://ncbi.nlm.nih.gov/pubmed/21270240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0446
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