Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

Inflammation, which is directly regulated by interleukin-6 (IL-6) signaling, is implicated in the etiology of several chronic diseases. Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with...

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में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ferreira, Ricardo C., Freitag, Daniel F., Cutler, Antony J., Howson, Joanna M. M., Rainbow, Daniel B., Smyth, Deborah J., Kaptoge, Stephen, Clarke, Pamela, Boreham, Charlotte, Coulson, Richard M., Pekalski, Marcin L., Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S., Butterworth, Adam S., Malarstig, Anders, Danesh, John, Todd, John A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2013
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617094/
https://ncbi.nlm.nih.gov/pubmed/23593036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003444
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