IL6 receptor(358)Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis

OBJECTIVE: To test the hypothesis that patients with amyotrophic lateral sclerosis (ALS) inheriting the common interleukin 6 receptor (IL6R) coding variant (Asp(358)Ala, rs2228145, C allele) have associated increases in interleukin 6 (IL6) and IL6R levels in serum and CSF and faster disease progress...

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Detalhes bibliográficos
Publicado no:Neurol Neuroimmunol Neuroinflamm
Main Authors: Wosiski-Kuhn, Marlena, Robinson, Mac, Strupe, Jane, Arounleut, Phonepasong, Martin, Matthew, Caress, James, Cartwright, Michael, Bowser, Robert, Cudkowicz, Merit, Langefeld, Carl, Hawkins, Gregory A., Milligan, Carol
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6865852/
https://ncbi.nlm.nih.gov/pubmed/31611269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000631
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