Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

Variation in the human leukocyte antigen (HLA) genes accounts for one-half of the genetic risk in type 1 diabetes (T1D). Amino acid changes in the HLA-DR and HLA-DQ molecules mediate most of the risk, but extensive linkage disequilibrium complicates the localization of independent effects. Using 18,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Hu, Xinli, Deutsch, Aaron J, Lenz, Tobias L, Onengut-Gumuscu, Suna, Han, Buhm, Chen, Wei-Min, Howson, Joanna M M, Todd, John A, de Bakker, Paul I W, Rich, Stephen S, Raychaudhuri, Soumya
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930791/
https://ncbi.nlm.nih.gov/pubmed/26168013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3353
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados