The use of RNAi-based screens to identify host proteins involved in viral replication

Por Hirsch, Alec J
Publicado em 2010

Human Cytomegalovirus Inhibits Transcription of the CC Chemokine MCP-1 Gene

Por Hirsch, Alec J., Shenk, Thomas
Publicado em 1999

A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection

Por Smith, Jessica L., Jeng, Sophia, McWeeney, Shannon K., Hirsch, Alec J.
Publicado no J Virol (2017)

Key role of T cell defects in age-related vulnerability to West Nile virus

Por Brien, James D., Uhrlaub, Jennifer L., Hirsch, Alec, Wiley, Clayton A., Nikolich-Žugich, Janko
Publicado em 2009

West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of αvβ3 Integrin

Por Medigeshi, Guruprasad R., Hirsch, Alec J., Streblow, Daniel N., Nikolich-Zugich, Janko, Nelson, Jay A.
Publicado em 2008

Induction of the Cellular MicroRNA, Hs_154, by West Nile Virus Contributes to Virus-Mediated Apoptosis through Repression of Antiapoptotic Factors

Por Smith, Jessica L., Grey, Finn E., Uhrlaub, Jennifer L., Nikolich-Zugich, Janko, Hirsch, Alec J.
Publicado em 2012

Human Cytomegalovirus-Encoded G Protein-Coupled Receptor US28 Mediates Smooth Muscle Cell Migration through Gα12

Por Melnychuk, Ryan M., Streblow, Daniel N., Smith, Patricia P., Hirsch, Alec J., Pancheva, Dora, Nelson, Jay A.
Publicado em 2004

The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus Particles

Por Hirsch, Alec J., Medigeshi, Guruprasad R., Meyers, Heather L., DeFilippis, Victor, Früh, Klaus, Briese, Thomas, Lipkin, W. Ian, Nelson, Jay A.
Publicado em 2005

Sultam Thiourea Inhibition of West Nile Virus

Por Barklis, Eric, Still, Amelia, Sabri, Mohammad I., Hirsch, Alec J., Nikolich-Zugich, Janko, Brien, James, Dhenub, Tenzin Choesang, Scholz, Isabel, Alfadhli, Ayna
Publicado em 2007

High-Content Assay to Identify Inhibitors of Dengue Virus Infection

Por Shum, David, Smith, Jessica L., Hirsch, Alec J., Bhinder, Bhavneet, Radu, Constantin, Stein, David A., Nelson, Jay A., Früh, Klaus, Djaballah, Hakim
Publicado em 2010

West Nile Virus Capsid Degradation of Claudin Proteins Disrupts Epithelial Barrier Function

Por Medigeshi, Guruprasad R., Hirsch, Alec J., Brien, James D., Uhrlaub, Jennifer L., Mason, Peter W., Wiley, Clayton, Nikolich-Zugich, Janko, Nelson, Jay A.
Publicado em 2009

Inhibition of Dengue Virus Replication by a Class of Small-Molecule Compounds That Antagonize Dopamine Receptor D4 and Downstream Mitogen-Activated Protein Kinase Signaling

Por Smith, Jessica L., Stein, David A., Shum, David, Fischer, Matthew A., Radu, Constantin, Bhinder, Bhavneet, Djaballah, Hakim, Nelson, Jay A., Früh, Klaus, Hirsch, Alec J.
Publicado em 2014

Flaviviruses Are Sensitive to Inhibition of Thymidine Synthesis Pathways

Por Fischer, Matthew A., Smith, Jessica L., Shum, David, Stein, David A., Parkins, Christopher, Bhinder, Bhavneet, Radu, Constantin, Hirsch, Alec J., Djaballah, Hakim, Nelson, Jay A., Früh, Klaus
Publicado em 2013

West Nile Virus Infection Activates the Unfolded Protein Response, Leading to CHOP Induction and Apoptosis

Por Medigeshi, Guruprasad R., Lancaster, Alissa M., Hirsch, Alec J., Briese, Thomas, Lipkin, W. Ian, DeFilippis, Victor, Früh, Klaus, Mason, Peter W., Nikolich-Zugich, Janko, Nelson, Jay A.
Publicado em 2007

Inhibition of Dengue Virus Infections in Cell Cultures and in AG129 Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence

Por Stein, David A., Perry, Stuart T., Buck, Michael D., Oehmen, Christopher S., Fischer, Matthew A., Poore, Elizabeth, Smith, Jessica L., Lancaster, Alissa M., Hirsch, Alec J., Slifka, Mark K., Nelson, Jay A., Shresta, Sujan, Früh, Klaus
Publicado em 2011

Immune Response to the West Nile Virus in Aged Non-Human Primates

Por Wertheimer, Anne M., Uhrlaub, Jennifer L., Hirsch, Alec, Medigeshi, Guruprasad, Sprague, Jerald, Legasse, Alfred, Wilk, Jennifer, Wiley, Clayton A., Didier, Peter, B. Tesh, Robert, Murray, Kristy O., Axthelm, Michael K., Wong, Scott W., Nikolich-Žugich, Janko
Publicado em 2010

A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses

Por Pryke, Kara M., Abraham, Jinu, Sali, Tina M., Gall, Bryan J., Archer, Iris, Liu, Andrew, Bambina, Shelly, Baird, Jason, Gough, Michael, Chakhtoura, Marita, Haddad, Elias K., Kirby, Ilsa T., Nilsen, Aaron, Streblow, Daniel N., Hirsch, Alec J., Smith, Jessica L., DeFilippis, Victor R.
Publicado no mBio (2017)

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

Por Hirsch, Alec J., Smith, Jessica L., Haese, Nicole N., Broeckel, Rebecca M., Parkins, Christopher J., Kreklywich, Craig, DeFilippis, Victor R., Denton, Michael, Smith, Patricia P., Messer, William B., Colgin, Lois M. A., Ducore, Rebecca M., Grigsby, Peta L., Hennebold, Jon D., Swanson, Tonya, Legasse, Alfred W., Axthelm, Michael K., MacAllister, Rhonda, Wiley, Clayton A., Nelson, Jay A., Streblow, Daniel N.
Publicado no PLoS Pathog (2017)

Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

Por Hirsch, Alec J., Smith, Jessica L., Haese, Nicole N., Broeckel, Rebecca M., Parkins, Christopher J., Kreklywich, Craig, DeFilippis, Victor R., Denton, Michael, Smith, Patricia P., Messer, William B., Colgin, Lois M. A., Ducore, Rebecca M., Grigsby, Peta L., Hennebold, Jon D., Swanson, Tonya, Legasse, Alfred W., Axthelm, Michael K., MacAllister, Rhonda, Wiley, Clayton A., Nelson, Jay A., Streblow, Daniel N.
Publicado no PLoS Pathog (2017)

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Por Hirsch, Alec J., Roberts, Victoria H. J., Grigsby, Peta L., Haese, Nicole, Schabel, Matthias C., Wang, Xiaojie, Lo, Jamie O., Liu, Zheng, Kroenke, Christopher D., Smith, Jessica L., Kelleher, Meredith, Broeckel, Rebecca, Kreklywich, Craig N., Parkins, Christopher J., Denton, Michael, Smith, Patricia, DeFilippis, Victor, Messer, William, Nelson, Jay A., Hennebold, Jon D., Grafe, Marjorie, Colgin, Lois, Lewis, Anne, Ducore, Rebecca, Swanson, Tonya, Legasse, Alfred W., Axthelm, Michael K., MacAllister, Rhonda, Moses, Ashlee V., Morgan, Terry K., Frias, Antonio E., Streblow, Daniel N.
Publicado no Nat Commun (2018)