Sultam Thiourea Inhibition of West Nile Virus

We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas ca...

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Detalhes bibliográficos
Main Authors: Barklis, Eric, Still, Amelia, Sabri, Mohammad I., Hirsch, Alec J., Nikolich-Zugich, Janko, Brien, James, Dhenub, Tenzin Choesang, Scholz, Isabel, Alfadhli, Ayna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913232/
https://ncbi.nlm.nih.gov/pubmed/17452483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00007-07
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