A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses

The ongoing concurrent outbreaks of Zika, Chikungunya, and dengue viruses in Latin America and the Caribbean highlight the need for development of broad-spectrum antiviral treatments. The type I interferon (IFN) system has evolved in vertebrates to generate tissue responses that actively block repli...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Pryke, Kara M., Abraham, Jinu, Sali, Tina M., Gall, Bryan J., Archer, Iris, Liu, Andrew, Bambina, Shelly, Baird, Jason, Gough, Michael, Chakhtoura, Marita, Haddad, Elias K., Kirby, Ilsa T., Nilsen, Aaron, Streblow, Daniel N., Hirsch, Alec J., Smith, Jessica L., DeFilippis, Victor R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414005/
https://ncbi.nlm.nih.gov/pubmed/28465426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00452-17
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