Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner

The innate immune response to cytosolic DNA involves transcriptional activation of type I interferons (IFN-I) and proinflammatory cytokines. This represents the culmination of intracellular signaling pathways that are initiated by pattern recognition receptors that engage DNA and require the adaptor...

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Publicado no:Front Immunol
Main Authors: Abraham, Jinu, Botto, Sara, Mizuno, Nobuyo, Pryke, Kara, Gall, Bryan, Boehm, Dylan, Sali, Tina M., Jin, Haihong, Nilsen, Aaron, Gough, Michael, Baird, Jason, Chakhtoura, Marita, Subra, Caroline, Trautmann, Lydie, Haddad, Elias K., DeFilippis, Victor R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360819/
https://ncbi.nlm.nih.gov/pubmed/32733475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01430
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