Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

Pharmacologic stimulation of innate immune processes represents an attractive strategy to achieve multiple therapeutic outcomes including inhibition of virus replication, boosting antitumor immunity, and enhancing vaccine immunogenicity. In light of this we sought to identify small molecules capable...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Sali, Tina M., Pryke, Kara M., Abraham, Jinu, Liu, Andrew, Archer, Iris, Broeckel, Rebecca, Staverosky, Julia A., Smith, Jessica L., Al-Shammari, Ahmed, Amsler, Lisi, Sheridan, Kayla, Nilsen, Aaron, Streblow, Daniel N., DeFilippis, Victor R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672893/
https://ncbi.nlm.nih.gov/pubmed/26646986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005324
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