Inhibition of Dengue Virus Replication by a Class of Small-Molecule Compounds That Antagonize Dopamine Receptor D4 and Downstream Mitogen-Activated Protein Kinase Signaling

Dengue viruses (DENV) are endemic pathogens of tropical and subtropical regions that cause significant morbidity and mortality worldwide. To date, no vaccines or antiviral therapeutics have been approved for combating DENV-associated disease. In this paper, we describe a class of tricyclic small-mol...

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Main Authors: Smith, Jessica L., Stein, David A., Shum, David, Fischer, Matthew A., Radu, Constantin, Bhinder, Bhavneet, Djaballah, Hakim, Nelson, Jay A., Früh, Klaus, Hirsch, Alec J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019099/
https://ncbi.nlm.nih.gov/pubmed/24599995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00365-14
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