A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

Por Schroeder, Courtney M, Ostrem, Jonathan ML, Hertz, Nicholas T, Vale, Ronald D
Publicado no eLife (2014)

Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen

Por Levin, Rebecca S., Hertz, Nicholas T., Burlingame, Alma L., Shokat, Kevan M., Mukherjee, Shaeri
Publicado no Proc Natl Acad Sci U S A (2016)

A neo-substrate that amplifies catalytic activity of Parkinson’s disease related kinase PINK1

Por Hertz, Nicholas T., Berthet, Amandine, Sos, Martin L., Thorn, Kurt S., Burlingame, Al L., Nakamura, Ken, Shokat, Kevan M.
Publicado em 2013

Chemical Genetic Approach for Kinase-Substrate Mapping by Covalent Capture of Thiophosphopeptides and Analysis by Mass Spectrometry

Por Hertz, Nicholas T., Wang, Beatrice T., Allen, Jasmina J., Zhang, Chao, Dar, Arvin C., Burlingame, Alma L., Shokat, Kevan M.
Publicado em 2010

Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease

Por Orr, Adam L., Rutaganira, Florentine U., de Roulet, Daniel, Huang, Eric J., Hertz, Nicholas T., Shokat, Kevan M., Nakamura, Ken
Publicado no Neurochem Int (2017)

Axon degeneration gated by retrograde activation of somatic pro-apoptotic signaling

Por Simon, David J., Pitts, Jason, Hertz, Nicholas T., Yang, Jing, Yamagishi, Yuya, Olsen, Olav, Mark, Milica Tešić, Molina, Henrik, Tessier-Lavigne, Marc
Publicado no Cell (2016)

Development of a Chemical Genetic Approach for Human Aurora B Kinase Identifies Novel Substrates of the Chromosomal Passenger Complex

Por Hengeveld, Rutger C. C., Hertz, Nicholas T., Vromans, Martijn J. M., Zhang, Chao, Burlingame, Alma L., Shokat, Kevan M., Lens, Susanne M. A.
Publicado em 2012

Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 uncovers their roles in controlling dendrite arborization and spine development

Por Ultanir, Sila K., Hertz, Nicholas T., Li, Guangnan, Ge, Woo-Ping, Burlingame, Alma L., Pleasure, Samuel J., Shokat, Kevan M., Jan, Lily Yeh, Jan, Yuh-Nung
Publicado em 2012

MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin Va Function in Promoting Spine Synapse Development

Por Ultanir, Sila K., Yadav, Smita, Hertz, Nicholas T., Oses-Prieto, Juan A., Claxton, Suzanne, Burlingame, Alma L., Shokat, Kevan M., Jan, Lily Y., Jan, Yuh-Nung
Publicado no Neuron (2014)

Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction

Por Schaffer, Bethany E., Levin, Rebecca S., Hertz, Nicholas T., Maures, Travis J., Schoof, Michael L., Hollstein, Pablo E., Benayoun, Bérénice A., Banko, Max R., Shaw, Reuben J., Shokat, Kevan M., Brunet, Anne
Publicado no Cell Metab (2015)

Drugging MYCN through an allosteric transition in Aurora Kinase A

Por Gustafson, William Clay, Meyerowitz, Justin Gabriel, Nekritz, Erin A., Chen, Justin, Benes, Cyril, Charron, Elise, Simonds, Erin Fitzgerald, Seeger, Robert, Matthay, Katherine, Hertz, Nicholas T., Eilers, Martin, Shokat, Kevan M., Weiss, William A.
Publicado em 2014

N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

Por Bowie, Laura E., Maiuri, Tamara, Alpaugh, Melanie, Gabriel, Michelle, Arbez, Nicolas, Galleguillos, Danny, Hung, Claudia L. K., Patel, Shreya, Xia, Jianrun, Hertz, Nicholas T., Ross, Christopher A., Litchfield, David W., Sipione, Simonetta, Truant, Ray
Publicado no Proc Natl Acad Sci U S A (2018)

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity

Por Kramer, Nicholas J., Haney, Michael S., Morgens, David W., Jovičić, Ana, Couthouis, Julien, Li, Amy, Ousey, James, Ma, Rosanna, Bieri, Gregor, Tsui, C. Kimberly, Shi, Yingxiao, Hertz, Nicholas T., Tessier-Lavigne, Marc, Ichida, Justin K., Bassik, Michael C., Gitler, Aaron D.
Publicado no Nat Genet (2018)