A neo-substrate that amplifies catalytic activity of Parkinson’s disease related kinase PINK1

Mitochondria have long been implicated in the pathogenesis of Parkinson’s disease (PD). Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with mitochondrial defects and result in an autosomal recessive form of early onset PD. Therapeutic approaches for enhancing...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hertz, Nicholas T., Berthet, Amandine, Sos, Martin L., Thorn, Kurt S., Burlingame, Al L., Nakamura, Ken, Shokat, Kevan M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950538/
https://ncbi.nlm.nih.gov/pubmed/23953109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.030
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