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Chemically reprogramming the phospho‐transfer reaction to crosslink protein kinases to their substrates

The proteomic mapping of enzyme–substrate interactions is challenged by their transient nature. A method to capture interacting protein kinases in complexes with a single substrate of interest would provide a new tool for mapping kinase signaling networks. Here, we describe a nucleotide‐based substr...

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Dades bibliogràfiques
Publicat a:Protein Sci
Autors principals: Wong, Allison W., Urisman, Anatoly, Burlingame, Alma L., Shokat, Kevan M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6371225/
https://ncbi.nlm.nih.gov/pubmed/30636329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3570
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