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Chemically reprogramming the phospho‐transfer reaction to crosslink protein kinases to their substrates

The proteomic mapping of enzyme–substrate interactions is challenged by their transient nature. A method to capture interacting protein kinases in complexes with a single substrate of interest would provide a new tool for mapping kinase signaling networks. Here, we describe a nucleotide‐based substr...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Wong, Allison W., Urisman, Anatoly, Burlingame, Alma L., Shokat, Kevan M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6371225/
https://ncbi.nlm.nih.gov/pubmed/30636329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3570
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