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A neo-substrate that amplifies catalytic activity of Parkinson’s disease related kinase PINK1
Mitochondria have long been implicated in the pathogenesis of Parkinson’s disease (PD). Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with mitochondrial defects and result in an autosomal recessive form of early onset PD. Therapeutic approaches for enhancing...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3950538/ https://ncbi.nlm.nih.gov/pubmed/23953109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.030 |
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