Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease

Mutations in the mitochondrial kinase PTEN-induced putative kinase 1 (PINK1) cause Parkinson's disease (PD), likely by disrupting PINK1's kinase activity. Although the mechanism(s) underlying how this loss of activity causes degeneration remains unclear, increasing PINK1 activity may thera...

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Veröffentlicht in:Neurochem Int
Hauptverfasser: Orr, Adam L., Rutaganira, Florentine U., de Roulet, Daniel, Huang, Eric J., Hertz, Nicholas T., Shokat, Kevan M., Nakamura, Ken
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641232/
https://ncbi.nlm.nih.gov/pubmed/28434973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2017.04.006
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