Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture

Cryptosporidiosis is a serious diarrheal disease in immunocompromised patients and malnourished children, and treatment is complicated by a lack of adequate drugs. Recent studies suggest that the natural occurrence of a small gatekeeper residue in serine threonine calcium-dependent protein kinase 1...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Kuhlenschmidt, Theresa B., Rutaganira, Florentine U., Long, Shaojun, Tang, Keliang, Shokat, Kevan M., Kuhlenschmidt, Mark S., Sibley, L. David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704151/
https://ncbi.nlm.nih.gov/pubmed/26552986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01915-15
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