Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii

Calcium dependent protein kinase 1 (CDPK1) is an essential enzyme in the opportunistic pathogen Toxoplasma gondii. CDPK1 controls multiple processes that are essential to the intracellular replicative cycle of T. gondii including secretion of adhesins, motility, invasion, and egress. Remarkably, CDP...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Med Chem
Hauptverfasser: Rutaganira, Florentine U., Barks, Jennifer, Dhason, Mary Savari, Wang, Qiuling, Lopez, Michael S., Long, Shaojun, Radke, Joshua B., Jones, Nathaniel G., Maddirala, Amarendar R., Janetka, James W., Bakkouri, Majida El, Hui, Raymond, Shokat, Kevan M., Sibley, L. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746462/
https://ncbi.nlm.nih.gov/pubmed/28933846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01192
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge