Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System

Recombinant adeno-associated viral vectors display efficient tropism for transduction of the dopamine neurons of the substantia nigra. Taking advantage of this unique property of recombinant adeno-associated viral vectors, we expressed wild-type and A53T mutated human α-synuclein in the nigrostriata...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kirik, Deniz, Rosenblad, Carl, Burger, Corinna, Lundberg, Cecilia, Johansen, Teit E., Muzyczka, Nicholas, Mandel, Ronald J., Björklund, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758323/
https://ncbi.nlm.nih.gov/pubmed/11923443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-07-02780.2002
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