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Overexpression of Glial Cell Line-Derived Neurotrophic Factor Using a Lentiviral Vector Induces Time- and Dose-Dependent Downregulation of Tyrosine Hydroxylase in the Intact Nigrostriatal Dopamine System

The effects of continuous glial cell line-derived neurotrophic factor (GDNF) overexpression in the intact nigrostriatal dopamine (DA) system was studied using recombinant lentiviral (rLV) vector delivery of GDNF to the striatum or substantia nigra (SN) in the rat. Intrastriatal delivery of rLV-GDNF...

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書誌詳細
出版年:J Neurosci
主要な著者: Georgievska, Biljana, Kirik, Deniz, Björklund, Anders
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729873/
https://ncbi.nlm.nih.gov/pubmed/15269253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1122-04.2004
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