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Overexpression of Glial Cell Line-Derived Neurotrophic Factor Using a Lentiviral Vector Induces Time- and Dose-Dependent Downregulation of Tyrosine Hydroxylase in the Intact Nigrostriatal Dopamine System

The effects of continuous glial cell line-derived neurotrophic factor (GDNF) overexpression in the intact nigrostriatal dopamine (DA) system was studied using recombinant lentiviral (rLV) vector delivery of GDNF to the striatum or substantia nigra (SN) in the rat. Intrastriatal delivery of rLV-GDNF...

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Pubblicato in:J Neurosci
Autori principali: Georgievska, Biljana, Kirik, Deniz, Björklund, Anders
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729873/
https://ncbi.nlm.nih.gov/pubmed/15269253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1122-04.2004
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