Overexpression of Glial Cell Line-Derived Neurotrophic Factor Using a Lentiviral Vector Induces Time- and Dose-Dependent Downregulation of Tyrosine Hydroxylase in the Intact Nigrostriatal Dopamine System

The effects of continuous glial cell line-derived neurotrophic factor (GDNF) overexpression in the intact nigrostriatal dopamine (DA) system was studied using recombinant lentiviral (rLV) vector delivery of GDNF to the striatum or substantia nigra (SN) in the rat. Intrastriatal delivery of rLV-GDNF...

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Vydáno v:J Neurosci
Hlavní autoři: Georgievska, Biljana, Kirik, Deniz, Björklund, Anders
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2004
Témata:
Development/Plasticity/Repair
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729873/
https://ncbi.nlm.nih.gov/pubmed/15269253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1122-04.2004
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