Lentivirally Delivered Glial Cell Line-Derived Neurotrophic Factor Increases the Number of Striatal Dopaminergic Neurons in Primate Models of Nigrostriatal Degeneration

The primate striatum contains tyrosine hydroxylase (TH)-immunoreactive (ir) neurons, the numbers of which are augmented after dopamine depletion. Glial cell line-derived neurotrophic factor (GDNF) strongly modulates the viability and phenotypic expression of dopamine ventral mesencephalic neurons. T...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Palfi, Stephane, Leventhal, Liza, Chu, Yaping, Ma, Shuang Y., Emborg, Marina, Bakay, Roy, Déglon, Nicole, Hantraye, Philippe, Aebischer, Patrick, Kordower, Jeffrey H.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757756/
https://ncbi.nlm.nih.gov/pubmed/12077191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-12-04942.2002
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