N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

The huntingtin N17 domain is a modulator of mutant huntingtin toxicity and is hypophosphorylated in Huntington’s disease (HD). We conducted high-content analysis to find compounds that could restore N17 phosphorylation. One lead compound from this screen was N6-furfuryladenine (N6FFA). N6FFA was pro...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Bowie, Laura E., Maiuri, Tamara, Alpaugh, Melanie, Gabriel, Michelle, Arbez, Nicolas, Galleguillos, Danny, Hung, Claudia L. K., Patel, Shreya, Xia, Jianrun, Hertz, Nicholas T., Ross, Christopher A., Litchfield, David W., Sipione, Simonetta, Truant, Ray
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064984/
https://ncbi.nlm.nih.gov/pubmed/29987005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801772115
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