N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

The huntingtin N17 domain is a modulator of mutant huntingtin toxicity and is hypophosphorylated in Huntington’s disease (HD). We conducted high-content analysis to find compounds that could restore N17 phosphorylation. One lead compound from this screen was N6-furfuryladenine (N6FFA). N6FFA was pro...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bowie, Laura E., Maiuri, Tamara, Alpaugh, Melanie, Gabriel, Michelle, Arbez, Nicolas, Galleguillos, Danny, Hung, Claudia L. K., Patel, Shreya, Xia, Jianrun, Hertz, Nicholas T., Ross, Christopher A., Litchfield, David W., Sipione, Simonetta, Truant, Ray
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064984/
https://ncbi.nlm.nih.gov/pubmed/29987005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801772115
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