N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

The huntingtin N17 domain is a modulator of mutant huntingtin toxicity and is hypophosphorylated in Huntington’s disease (HD). We conducted high-content analysis to find compounds that could restore N17 phosphorylation. One lead compound from this screen was N6-furfuryladenine (N6FFA). N6FFA was pro...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Bowie, Laura E., Maiuri, Tamara, Alpaugh, Melanie, Gabriel, Michelle, Arbez, Nicolas, Galleguillos, Danny, Hung, Claudia L. K., Patel, Shreya, Xia, Jianrun, Hertz, Nicholas T., Ross, Christopher A., Litchfield, David W., Sipione, Simonetta, Truant, Ray
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2018
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064984/
https://ncbi.nlm.nih.gov/pubmed/29987005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801772115
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