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High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry
Huntington's disease (HD) is a neurodegenerative, age-onset disorder caused by a CAG DNA expansion in exon 1 of the HTT gene, resulting in a polyglutamine expansion in the huntingtin protein. Nuclear accumulation of mutant huntingtin is a hallmark of HD, resulting in elevated mutant huntingtin...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6369305/ https://ncbi.nlm.nih.gov/pubmed/30538129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001440 |
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