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Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization

The N17 domain of the huntingtin protein is post-translationally modified and is the master regulator of huntingtin intracellular localization. In Huntington’s disease (HD), mutant huntingtin is hypo-phosphorylated at serines 13 and 16 within N17, and increasing N17 phosphorylation has been shown to...

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Detalles Bibliográficos
Publicado en:Hum Mol Genet
Main Authors: DiGiovanni, Laura F., Mocle, Andrew J., Xia, Jianrun, Truant, Ray
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291230/
https://ncbi.nlm.nih.gov/pubmed/27466181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw234
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