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Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization
The N17 domain of the huntingtin protein is post-translationally modified and is the master regulator of huntingtin intracellular localization. In Huntington’s disease (HD), mutant huntingtin is hypo-phosphorylated at serines 13 and 16 within N17, and increasing N17 phosphorylation has been shown to...
Guardado en:
| Publicado en: | Hum Mol Genet |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291230/ https://ncbi.nlm.nih.gov/pubmed/27466181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw234 |
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