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The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal
The first 17 amino acids of Huntington’s disease (HD) protein, huntingtin, comprise an amphipathic alpha-helical domain that can target huntingtin to the endoplasmic reticulum (ER). N17 is phosphorylated at two serines, shown to be important for disease development in genetic mouse models, and shown...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596850/ https://ncbi.nlm.nih.gov/pubmed/23297360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds554 |
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