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An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1
The karyopherin CRM1 mediates nuclear export of proteins and ribonucleoproteins bearing a leucine-rich nuclear export signal (NES). To elucidate the precise mechanism by which NES-cargos are dissociated from CRM1 in the cytoplasm, which is important for transport directionality, we determined a 2.0-...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892370/ https://ncbi.nlm.nih.gov/pubmed/20485264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.89 |
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