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An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1
The karyopherin CRM1 mediates nuclear export of proteins and ribonucleoproteins bearing a leucine-rich nuclear export signal (NES). To elucidate the precise mechanism by which NES-cargos are dissociated from CRM1 in the cytoplasm, which is important for transport directionality, we determined a 2.0-...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892370/ https://ncbi.nlm.nih.gov/pubmed/20485264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.89 |
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