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An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1

The karyopherin CRM1 mediates nuclear export of proteins and ribonucleoproteins bearing a leucine-rich nuclear export signal (NES). To elucidate the precise mechanism by which NES-cargos are dissociated from CRM1 in the cytoplasm, which is important for transport directionality, we determined a 2.0-...

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Bibliografiske detaljer
Main Authors: Koyama, Masako, Matsuura, Yoshiyuki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892370/
https://ncbi.nlm.nih.gov/pubmed/20485264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.89
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