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The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal
The first 17 amino acids of Huntington’s disease (HD) protein, huntingtin, comprise an amphipathic alpha-helical domain that can target huntingtin to the endoplasmic reticulum (ER). N17 is phosphorylated at two serines, shown to be important for disease development in genetic mouse models, and shown...
Sparad:
| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596850/ https://ncbi.nlm.nih.gov/pubmed/23297360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds554 |
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