Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

Huntington disease (HD) is a progressive neurodegenerative monogenic disorder caused by expansion of a polyglutamine stretch in the huntingtin (Htt) protein. Mutant huntingtin triggers neural dysfunction and death, mainly in the corpus striatum and cerebral cortex, resulting in pathognomonic motor s...

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Главные авторы: Di Pardo, Alba, Maglione, Vittorio, Alpaugh, Melanie, Horkey, Melanie, Atwal, Randy S., Sassone, Jenny, Ciammola, Andrea, Steffan, Joan S., Fouad, Karim, Truant, Ray, Sipione, Simonetta
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295265/
https://ncbi.nlm.nih.gov/pubmed/22331905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114502109
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