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Impaired Ganglioside Metabolism in Huntington's Disease and Neuroprotective Role of GM1
Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine stretch in the protein huntingtin (Htt). HD neurons are dysfunctional at multiple levels and have increased susceptibility to stress and apoptotic stimuli. We have discovered that synthesis of t...
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| Publié dans: | J Neurosci |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Neuroscience
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6632269/ https://ncbi.nlm.nih.gov/pubmed/20237277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6348-09.2010 |
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