Drugging MYCN through an allosteric transition in Aurora Kinase A

MYC proteins are major drivers of cancer, yet are considered undruggable, as their DNA binding domains are composed of two extended alpha helices with no apparent surfaces for small molecule binding. Proteolytic degradation of MYCN protein is regulated in part by a kinase-independent function of Aur...

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Main Authors: Gustafson, William Clay, Meyerowitz, Justin Gabriel, Nekritz, Erin A., Chen, Justin, Benes, Cyril, Charron, Elise, Simonds, Erin Fitzgerald, Seeger, Robert, Matthay, Katherine, Hertz, Nicholas T., Eilers, Martin, Shokat, Kevan M., Weiss, William A.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160413/
https://ncbi.nlm.nih.gov/pubmed/25175806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.07.015
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