BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina

by Harder, Jeffrey M, Libby, Richard T
Published 2011

The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice

by Harder, Jeffrey M., Fernandes, Kimberly A., Libby, Richard T.
Published 2012

JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells

by Fernandes, Kimberly A, Harder, Jeffrey M., Kim, Jessica, Libby, Richard T.
Published 2013

Glaucoma as a metabolic optic neuropathy: making the case for nicotinamide treatment in glaucoma

by Williams, Pete A, Harder, Jeffrey M, John, Simon W M
Published in J Glaucoma (2017)

DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury

by Fernandes, Kimberly A., Harder, Jeffrey M., John, Simon W., Shrager, Peter, Libby, Richard T.
Published 2014

Animal models of exfoliation syndrome, now and future

by John, Simon W. M., Harder, Jeffrey M., Fingert, John H., Anderson, Michael G.
Published in J Glaucoma (2014)

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

by Tribble, James R., Harder, Jeffrey M., Williams, Pete A., John, Simon W. M.
Published in Mol Brain (2020)

BCL2L1 (BCL-x) promotes survival of adult and developing retinal ganglion cells

by Harder, Jeffrey M., Ding, Qian, Fernandes, Kimberly A, Cherry, Jonathan D., Gan, Lin, Libby, Richard T.
Published 2012

Nicotinamide treatment robustly protects from inherited mouse glaucoma

by Williams, Pete A., Harder, Jeffrey M., Cardozo, Brynn H., Foxworth, Nicole E., John, Simon W. M.
Published in Commun Integr Biol (2018)

Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease

by Graham, Leah C., Harder, Jeffrey M., Soto, Ileana, de Vries, Wilhelmine N., John, Simon W. M., Howell, Gareth R.
Published in Sci Rep (2016)

Nicotinamide and WLD(S) Act Together to Prevent Neurodegeneration in Glaucoma

by Williams, Pete A., Harder, Jeffrey M., Foxworth, Nicole E., Cardozo, Brynn H., Cochran, Kelly E., John, Simon W. M.
Published in Front Neurosci (2017)

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

by Fernandes, Kimberly A., Harder, Jeffrey M., Fornarola, Laura B, Freeman, Robert S, Clark, Abbot F., Pang, Iok-Hou, John, Simon W.M., Libby, Richard T.
Published 2012

Vitamin B(3) modulates mitochondrial vulnerability and prevents glaucoma in aged mice

by Williams, Pete A, Harder, Jeffrey M, Foxworth, Nicole E, Cochran, Kelly E, Philip, Vivek M, Porciatti, Vittorio, Smithies, Oliver, John, Simon W M
Published in Science (2017)

Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice

by Harder, Jeffrey M., Williams, Pete A., Soto, Ileana, Foxworth, Nicole E., Fernandes, Kimberly A., Freeburg, Nelson F., Libby, Richard T., John, Simon. W. M.
Published in Cell Death Dis (2018)

Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

by Harder, Jeffrey M., Williams, Pete A., Braine, Catherine E., Yang, Hongtian S., Thomas, Jocelyn M., Foxworth, Nicole E., John, Simon W. M., Howell, Gareth R.
Published in J Neuroinflammation (2020)

Using Genetic Mouse Models to Gain Insight into Glaucoma: Past Results and Future Possibilities

by Fernandes, Kimberly A., Harder, Jeffrey M., Williams, Pete A., Rausch, Rebecca L., Kiernan, Amy E., Nair, K. Saidas, Anderson, Michael G., John, Simon W., Howell, Gareth R., Libby, Richard T.
Published in Exp Eye Res (2015)

Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective

by Harder, Jeffrey M., Braine, Catherine E., Williams, Pete A., Zhu, Xianjun, MacNicoll, Katharine H., Sousa, Gregory L., Buchanan, Rebecca A., Smith, Richard S., Libby, Richard T., Howell, Gareth R., John, Simon W. M.
Published in Proc Natl Acad Sci U S A (2017)

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

by Williams, Pete A., Braine, Catherine E., Kizhatil, Krishnakumar, Foxworth, Nicole E., Tolman, Nicholas G., Harder, Jeffrey M., Scott, Rebecca A., Sousa, Gregory L., Panitch, Alyssa, Howell, Gareth R., John, Simon W. M.
Published in Mol Neurodegener (2019)

Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin

by Harder, Jeffrey M., Guymer, Chelsea, Wood, John P. M., Daskalaki, Evangelia, Chidlow, Glyn, Zhang, Chi, Balasubramanian, Revathi, Cardozo, Brynn H., Foxworth, Nicole E., Deering, Kelly E., Ouellette, Tionna B., Montgomery, Christa, Wheelock, Craig E., Casson, Robert J., Williams, Pete A., John, Simon W. M.
Published in Proc Natl Acad Sci U S A (2020)

A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome

by Aung, Tin, Ozaki, Mineo, Mizoguchi, Takanori, Allingham, R Rand, Li, Zheng, Haripriya, Aravind, Nakano, Satoko, Uebe, Steffen, Harder, Jeffrey M., Chan, Anita S.Y., Lee, Mei Chin, Burdon, Kathryn P., Astakhov, Yury S., Abu-Amero, Khaled K., Zenteno, Juan C., Nilgün, Yildirim, Zarnowski, Tomasz, Pakravan, Mohammad, Safieh, Leen Abu, Jia, Liyun, Wang, Ya Xing, Williams, Susan, Paoli, Daniela, Schlottmann, Patricio G, Huang, Lulin, Sim, Kar Seng, Foo, Jia Nee, Nakano, Masakazu, Ikeda, Yoko, Kumar, Rajesh S, Ueno, Morio, Manabe, Shin-ichi, Hayashi, Ken, Kazama, Shigeyasu, Ideta, Ryuichi, Mori, Yosai, Miyata, Kazunori, Sugiyama, Kazuhisa, Higashide, Tomomi, Chihara, Etsuo, Inoue, Kenji, Ishiko, Satoshi, Yoshida, Akitoshi, Yanagi, Masahide, Kiuchi, Yoshiaki, Aihara, Makoto, Ohashi, Tsutomu, Sakurai, Toshiya, Sugimoto, Takako, Chuman, Hideki, Matsuda, Fumihiko, Yamashiro, Kenji, Gotoh, Norimoto, Miyake, Masahiro, Astakhov, Sergei Y., Osman, Essam A., Al-Obeidan, Saleh A., Owaidhah, Ohoud, Al-Jasim, Leyla, Al Shahwan, Sami, Fogarty, Rhys A., Leo, Paul, Yetkin, Yaz, Oğuz, Çilingir, Kanavi, Mozhgan Rezaei, Beni, Afsaneh Naderi, Yazdani, Shahin, Akopov, Evgeny L., Toh, Kai-Yee, Howell, Gareth R, Orr, Andrew C., Goh, Yufen, Meah, Wee Yang, Peh, Su Qin, Kosior-Jarecka, Ewa, Lukasik, Urszula, Krumbiegel, Mandy, Vithana, Eranga N, Wong, Tien Yin, Liu, Yutao, Ashley Koch, Allison E., Challa, Pratap, Rautenbach, Robyn M, Mackey, David A., Hewitt, Alex W, Mitchell, Paul, Wang, Jie Jin, Ziskind, Ari, Carmichael, Trevor, Ramakrishnan, Rangappa, Narendran, Kalpana, Venkatesh, Rangaraj, Vijayan, Saravanan, Zhao, Peiquan, Chen, Xueyi, Guadarrama-Vallejo, Dalia, Cheng, Ching Yu, Perera, Shamira A, Husain, Rahat, Ho, Su-Ling, Welge-Luessen, Ulrich-Christoph, Mardin, Christian, Schloetzer-Schrehardt, Ursula, Hillmer, Axel M., Herms, Stefan, Moebus, Susanne, Nöthen, Markus M., Weisschuh, Nicole, Shetty, Rohit, Ghosh, Arkasubhra, Teo, Yik Ying, Brown, Matthew A, Lischinsky, Ignacio, Crowston, Jonathan G, Coote, Michael, Zhao, Bowen, Sang, Jinghong, Zhang, Nihong, You, Qisheng, Vysochinskaya, Vera, Founti, Panayiota, Chatzikyriakidou, Anthoula, Lambropoulos, Alexandros, Anastasopoulos, Eleftherios, Coleman, Anne L, Wilson, M Roy, Rhee, Douglas J, Kang, Jae Hee, May-Bolchakova, Inna, Heegaard, Steffen, Mori, Kazuhiko, Alward, Wallace L.M., Jonas, Jost B, Xu, Liang, Liebmann, Jeffrey M, Chowbay, Balram, Schaeffeler, Elke, Schwab, Matthias, Lerner, Fabian, Wang, Ningli, Yang, Zhenglin, Frezzotti, Paolo, Kinoshita, Shigeru, Fingert, John H., Inatani, Masaru, Tashiro, Kei, Reis, André, Edward, Deepak P., Pasquale, Louis R., Kubota, Toshiaki, Wiggs, Janey L., Pasutto, Francesca, Topouzis, Fotis, Dubina, Michael, Craig, Jamie E., Yoshimura, Nagahisa, Sundaresan, Periasamy, John, Simon W.M., Ritch, Robert, Hauser, Michael A, Khor, Chiea-Chuen
Published in Nat Genet (2015)