DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury

Injury to retinal ganglion cell (RGC) axons triggers rapid activation of Jun N-terminal kinase (JNK) signaling, a major prodeath pathway in injured RGCs. Of the multiple kinases that can activate JNK, dual leucine kinase (Dlk) is known to regulate both apoptosis and Wallerian degeneration triggered...

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Bibliographic Details
Main Authors: Fernandes, Kimberly A., Harder, Jeffrey M., John, Simon W., Shrager, Peter, Libby, Richard T.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099422/
https://ncbi.nlm.nih.gov/pubmed/24878510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.05.015
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