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DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury
Injury to retinal ganglion cell (RGC) axons triggers rapid activation of Jun N-terminal kinase (JNK) signaling, a major prodeath pathway in injured RGCs. Of the multiple kinases that can activate JNK, dual leucine kinase (Dlk) is known to regulate both apoptosis and Wallerian degeneration triggered...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4099422/ https://ncbi.nlm.nih.gov/pubmed/24878510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.05.015 |
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