Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin

Intraocular pressure-sensitive retinal ganglion cell degeneration is a hallmark of glaucoma, the leading cause of irreversible blindness. Here, we used RNA-sequencing and metabolomics to examine early glaucoma in DBA/2J mice. We demonstrate gene expression changes that significantly impact pathways...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Harder, Jeffrey M., Guymer, Chelsea, Wood, John P. M., Daskalaki, Evangelia, Chidlow, Glyn, Zhang, Chi, Balasubramanian, Revathi, Cardozo, Brynn H., Foxworth, Nicole E., Deering, Kelly E., Ouellette, Tionna B., Montgomery, Christa, Wheelock, Craig E., Casson, Robert J., Williams, Pete A., John, Simon W. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7776900/
https://ncbi.nlm.nih.gov/pubmed/33318177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014213117
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