Vitamin B(3) modulates mitochondrial vulnerability and prevents glaucoma in aged mice

Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly. The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging are unknown. Studying glaucoma-prone mice, we show that mitochondrial abnormalities are an early driver of neuronal dy...

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Udgivet i:Science
Main Authors: Williams, Pete A, Harder, Jeffrey M, Foxworth, Nicole E, Cochran, Kelly E, Philip, Vivek M, Porciatti, Vittorio, Smithies, Oliver, John, Simon W M
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408298/
https://ncbi.nlm.nih.gov/pubmed/28209901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal0092
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