The development of antibody –based immunotherapy with (EMD-273063) Hu14.18-IL2 in melanoma and neuroblastoma

Por Yamane, Brett H., Hank, Jacquelyn A., Albertini, Mark R., Sondel, Paul M.
Publicado em 2009

NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer Immunotherapy

Por Wang, Wei, Erbe, Amy K., Hank, Jacquelyn A., Morris, Zachary S., Sondel, Paul M.
Publicado no Front Immunol (2015)

Rhamnose Glycoconjugates for the Recruitment of Endogenous Anti-carbohydrate Antibodies to Tumor Cells

Por Sheridan, Rachael T. C., Hudon, Jonathan, Hank, Jacquelyn A., Sondel, Paul M., Kiessling, Laura L.
Publicado em 2014

NK Cell-based Immunotherapies in Pediatric Oncology

Por McDowell, Kimberly A., Hank, Jacquelyn A., DeSantes, Kenneth B., Capitini, Christian M., Otto, Mario, Sondel, Paul M.
Publicado no J Pediatr Hematol Oncol (2015)

Increasing the Clinical Efficacy of NK and Antibody-Mediated Cancer Immunotherapy: Potential Predictors of Successful Clinical Outcome Based on Observations in High-Risk Neuroblast...

Por Koehn, Tony A., Trimble, Lori L., Alderson, Kory L., Erbe, Amy K., McDowell, Kimberly A., Grzywacz, Bartosz, Hank, Jacquelyn A., Sondel, Paul M.
Publicado em 2012

Immunogenicity of the Hu14.18-IL2 Immunocytokine Molecule in Adults with Melanoma and Children with Neuroblastoma

Por Hank, Jacquelyn A., Gan, Jacek, Ryu, Hyunji, Ostendorf, Amy, Stauder, Michael C., Sternberg, Adam, Albertini, Mark, Lo, Kin-Ming, Gillies, Stephen D., Eickhoff, Jens, Sondel, Paul M.
Publicado em 2009

Phase II trial of hu14.18-IL2 for patients with metastatic melanoma

Por Albertini, Mark R., Hank, Jacquelyn A., Gadbaw, Brian, Kostlevy, Jordan, Haldeman, Jennifer, Schalch, Heidi, Gan, Jacek, Kim, KyungMann, Eickhoff, Jens, Gillies, Stephen D., Sondel, Paul M.
Publicado em 2012

Phase I Study of ch14.18 With Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2 in Children With Neuroblastoma After Autologous Bone Marrow Transplantation or Stem...

Por Gilman, Andrew L., Ozkaynak, M. Fevzi, Matthay, Katherine K., Krailo, Mark, Yu, Alice L., Gan, Jacek, Sternberg, Adam, Hank, Jacquelyn A., Seeger, Robert, Reaman, Gregory H., Sondel, Paul M.
Publicado em 2009

Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface

Por Gubbels, Jennifer A. A., Gadbaw, Brian, Buhtoiarov, Ilia N., Horibata, Sachi, Kapur, Arvinder K., Patel, Dhara, Hank, Jacquelyn A., Gillies, Stephen D., Sondel, Paul M., Patankar, Manish S., Connor, Joseph
Publicado em 2011

Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy

Por Soto, Brenda L., Hank, Jacquelyn A., Darjatmoko, Soesiawati R., Polans, Arthur S., Yanke, Eric M., Rakhmilevich, Alexander L., Seo, Songwon, Kim, KyungMann, Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Publicado em 2011

Intratumoral Immunocytokine Treatment Results in Enhanced Antitumor Effects

Por Johnson, Erik E., Lum, Hillary D., Rakhmilevich, Alexander L., Schmidt, Brian E., Furlong, Meghan, Buhtoiarov, Ilia N., Hank, Jacquelyn A., Raubitschek, Andrew, Colcher, David, Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Publicado em 2008

Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting

Por Buhtoiarov, Ilia N., Neal, Zane C., Gan, Jacek, Buhtoiarova, Tatiana N., Patankar, Manish S., Gubbels, Jennifer A. A., Hank, Jacquelyn A., Yamane, Brett, Rakhmilevich, Alexander L., Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Publicado em 2011

Intratumoral hu14.18–IL-2 (IC) Induces Local and Systemic Antitumor Effects That Involve Both Activated T and NK Cells As Well As Enhanced IC Retention

Por Yang, Richard K., Kalogriopoulos, Nicholas A., Rakhmilevich, Alexander L., Ranheim, Erik A., Seo, Songwon, Kim, KyungMann, Alderson, Kory L., Gan, Jacek, Reisfeld, Ralph A., Gillies, Stephen D., Hank, Jacquelyn A., Sondel, Paul M.
Publicado em 2012

Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the Hu14.18 antibody increases intratumoral CD8+ T and NK cells...

Por Yang, Richard K., Kalogriopoulos, Nicholas A., Rakhmilevich, Alexander L., Ranheim, Erik A., Seo, Songwon, Kim, KyungMann, Alderson, Kory L., Gan, Jacek, Reisfeld, Ralph A., Gillies, Stephen D., Hank, Jacquelyn A., Sondel, Paul M.
Publicado em 2013

Immunocytokine augments local and abscopal response and animal survival when added to radiation and CTLA-4 checkpoint inhibition in a murine melanoma model

Por Morris, Zachary S, Guy, Emily I, Francis, David M, Gressett, Monica M, Armstrong, Eric A, Huang, Shyhmin, Gillies, Stephen D, Korman, Alan J, Hank, Jacquelyn A, Rakhmilevich, Alexander L, Harari, Paul M, Sondel, Paul M
Publicado no J Immunother Cancer (2015)

The anti-tumor effect of resveratrol alone or in combination with immunotherapy in a neuroblastoma model

Por Soto, Brenda L., Hank, Jacquelyn A., Van De Voort, Tyler J., Subramanian, Lalita, Polans, Arthur S., Rakhmilevich, Alexander L., Yang, Richard K., Seo, Songwong, Kim, KyungMann, Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Publicado em 2011

Phase I Clinical Trial of the Immunocytokine EMD 273063 in Melanoma Patients

Por King, David M., Albertini, Mark R., Schalch, Heidi, Hank, Jacquelyn A., Gan, Jacek, Surfus, Jean, Mahvi, David, Schiller, Joan H., Warner, Thomas, Kim, KyungMann, Eickhoff, Jens, Kendra, Kari, Reisfeld, Ralph, Gillies, Stephen D., Sondel, Paul
Publicado em 2004

StrataGraft skin substitute is well-tolerated and is not acutely immunogenic in patients with traumatic wounds: results from a prospective, randomized, controlled dose escalation t...

Por Centanni, John M., Straseski, Joely A., Wicks, April, Hank, Jacquelyn A., Rasmussen, Cathy A., Lokuta, Mary A., Schurr, Michael J., Foster, Kevin N., Faucher, Lee D., Caruso, Daniel M., Comer, Allen R., Allen-Hoffmann, B. Lynn
Publicado em 2011

Phase I study to evaluate toxicity and feasibility of intratumoral injection of α-gal glycolipids in patients with advanced melanoma

Por Albertini, Mark R., Ranheim, Erik A., Zuleger, Cindy L., Sondel, Paul M., Hank, Jacquelyn A., Bridges, Alan, Newton, Michael A., McFarland, Thomas, Collins, Jennifer, Clements, Erin, Henry, Mary Beth, Neuman, Heather B., Weber, Sharon, Whalen, Giles, Galili, Uri
Publicado no Cancer Immunol Immunother (2016)

A Phase I Clinical Trial of the hu14.18-IL2 (EMD 273063) as a Treatment for Children with Refractory or Recurrent Neuroblastoma and Melanoma: a Study of the Children’s Oncology Gro...

Por Osenga, Kaci L., Hank, Jacquelyn A., Albertini, Mark R., Gan, Jacek, Sternberg, Adam G., Eickhoff, Jens, Seeger, Robert C., Matthay, Katherine K., Reynolds, C. Patrick, Twist, Clare, Krailo, Mark, Adamson, Peter C., Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Publicado em 2006