Current and Potential Uses of Immunocytokines as Cancer Immunotherapy

Por Sondel, Paul M., Gillies, Stephen D.
Publicado em 2012

Tumor-targeted IL-2 amplifies T cell-mediated immune response induced by gene therapy with single-chain IL-12

Por Lode, Holger N., Xiang, Rong, Duncan, Steven R., Theofilopoulos, Argyrios N., Gillies, Stephen D., Reisfeld, Ralph A.
Publicado em 1999

Synergy between an antiangiogenic integrin α(v) antagonist and an antibody–cytokine fusion protein eradicates spontaneous tumor metastases

Por Lode, Holger N., Moehler, Thomas, Xiang, Rong, Jonczyk, Alfred, Gillies, Stephen D., Cheresh, David A., Reisfeld, Ralph A.
Publicado em 1999

Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction

Por Lode, Holger N., Xiang, Rong, Pertl, Ursula, Förster, Elisabeth, Schoenberger, Stephen P., Gillies, Stephen D., Reisfeld, Ralph A.
Publicado em 2000

Enhancement of the anti-melanoma response of Hu14.18K322A by αCD40 + CpG

Por Alderson, Kory L., Luangrath, Mitchell, Elsenheimer, Megan M., Gillies, Stephen D., Navid, Fariba, Rakhmilevich, Alexander L., Sondel, Paul M.
Publicado em 2012

Activation of innate and adaptive immunity as an effective combined strategy for cancer immunotherapy

Por Rakhmilevich, Alexander, Felder, Mildred, Lever, Lauren, Van De Voort, Tyler, Korman, Alan J, Gillies, Stephen D, Sondel, Paul M
Publicado no J Immunother Cancer (2015)

Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma

Por Gillies Stephen D, Kovar Andreas, Gooding William, Whiteside Theresa L, Atkins Michael B, Kirkwood John M, Ribas Antoni, Kashala Oscar, Morse Michael A
Publicado em 2009-07-01

Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma

Por Ribas, Antoni, Kirkwood, John M, Atkins, Michael B, Whiteside, Theresa L, Gooding, William, Kovar, Andreas, Gillies, Stephen D, Kashala, Oscar, Morse, Michael A
Publicado em 2009

Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia

Por Sorkin, Linda S., Otto, Mario, Baldwin, William M., Vail, Emily, Gillies, Stephen D., Handgretinger, Rupert, Barfield, Raymond C., Yu, Hui Ming, Yu, Alice L.
Publicado em 2010

Radiofrequency Ablation Combined with KS-IL2 Immunocytokine (EMD 273066) Results in an Enhanced Antitumor Effect Against Murine Colon Adenocarcinoma

Por Johnson, Erik E., Yamane, Brett H., Buhtoiarov, Ilia N., Lum, Hillary D., Rakhmilevich, Alexander L., Mahvi, David M., Gillies, Stephen D., Sondel, Paul M.
Publicado em 2009

Genetically Targeted Adenovirus Vector Directed to CD40-Expressing Cells

Por Belousova, Natalya, Korokhov, Nikolay, Krendelshchikova, Valentina, Simonenko, Vera, Mikheeva, Galina, Triozzi, Pierre L., Aldrich, Wayne A., Banerjee, Papia T., Gillies, Stephen D., Curiel, David T., Krasnykh, Victor
Publicado em 2003

Immunogenicity of the Hu14.18-IL2 Immunocytokine Molecule in Adults with Melanoma and Children with Neuroblastoma

Por Hank, Jacquelyn A., Gan, Jacek, Ryu, Hyunji, Ostendorf, Amy, Stauder, Michael C., Sternberg, Adam, Albertini, Mark, Lo, Kin-Ming, Gillies, Stephen D., Eickhoff, Jens, Sondel, Paul M.
Publicado em 2009

Phase II trial of hu14.18-IL2 for patients with metastatic melanoma

Por Albertini, Mark R., Hank, Jacquelyn A., Gadbaw, Brian, Kostlevy, Jordan, Haldeman, Jennifer, Schalch, Heidi, Gan, Jacek, Kim, KyungMann, Eickhoff, Jens, Gillies, Stephen D., Sondel, Paul M.
Publicado em 2012

Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface

Por Gubbels, Jennifer A. A., Gadbaw, Brian, Buhtoiarov, Ilia N., Horibata, Sachi, Kapur, Arvinder K., Patel, Dhara, Hank, Jacquelyn A., Gillies, Stephen D., Sondel, Paul M., Patankar, Manish S., Connor, Joseph
Publicado em 2011

Effective combination of innate and adaptive immunotherapeutic approaches in a mouse melanoma model

Por Rakhmilevich, Alexander L., Felder, Mildred, Lever, Lauren, Slowinski, Jacob, Rasmussen, Kayla, Hoefges, Anna, Van De Voort, Tyler J., Loibner, Hans, Korman, Alan J., Gillies, Stephen D., Sondel, Paul M.
Publicado no J Immunol (2017)

Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy

Por Soto, Brenda L., Hank, Jacquelyn A., Darjatmoko, Soesiawati R., Polans, Arthur S., Yanke, Eric M., Rakhmilevich, Alexander L., Seo, Songwon, Kim, KyungMann, Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Publicado em 2011

Intratumoral Immunocytokine Treatment Results in Enhanced Antitumor Effects

Por Johnson, Erik E., Lum, Hillary D., Rakhmilevich, Alexander L., Schmidt, Brian E., Furlong, Meghan, Buhtoiarov, Ilia N., Hank, Jacquelyn A., Raubitschek, Andrew, Colcher, David, Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Publicado em 2008

NK cells engineered to express a GD(2)-specific antigen receptor display built-in ADCC-like activity against tumour cells of neuroectodermal origin

Por Esser, Ruth, Müller, Tina, Stefes, Dörthe, Kloess, Stephan, Seidel, Diana, Gillies, Stephen D, Aperlo-Iffland, Christel, Huston, James S, Uherek, Christoph, Schönfeld, Kurt, Tonn, Torsten, Huebener, Nicole, Lode, Holger N, Koehl, Ulrike, Wels, Winfried S
Publicado em 2012

Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting

Por Buhtoiarov, Ilia N., Neal, Zane C., Gan, Jacek, Buhtoiarova, Tatiana N., Patankar, Manish S., Gubbels, Jennifer A. A., Hank, Jacquelyn A., Yamane, Brett, Rakhmilevich, Alexander L., Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Publicado em 2011

Intratumoral hu14.18–IL-2 (IC) Induces Local and Systemic Antitumor Effects That Involve Both Activated T and NK Cells As Well As Enhanced IC Retention

Por Yang, Richard K., Kalogriopoulos, Nicholas A., Rakhmilevich, Alexander L., Ranheim, Erik A., Seo, Songwon, Kim, KyungMann, Alderson, Kory L., Gan, Jacek, Reisfeld, Ralph A., Gillies, Stephen D., Hank, Jacquelyn A., Sondel, Paul M.
Publicado em 2012